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產(chǎn)品中心抗體Polyclonal AntibodyK106453PAnti-PDX1 Polyclonal Antibody
產(chǎn)品型號：K106453P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：1065
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產(chǎn)品分類
Anti-PDX1 Polyclonal Antibody
| 英文名稱 | Anti-PDX1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | GSF;IDX-1;IPF1;IUF1;MODY4;PAGEN1;PDX-1;STF-1 |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:2000-5000.IHC 1:50-200. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 48kDa |
| Gene ID | 3651 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human PDX1 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human PDX1 |
| Subcellular Locations | Cytoplasm Nucleus cytosol |
| Swiss Prot | P52945 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
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