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產(chǎn)品中心抗體Polyclonal AntibodyK106533PAnti-LAMP1 Polyclonal Antibody
產(chǎn)品型號：K106533P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：935
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產(chǎn)品分類
Anti-LAMP1 Polyclonal Antibody
| 英文名稱 | Anti-LAMP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | CD107a;LAMPA;LGP120;lgpA;OTTHUMP00000040663 |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:2000-5000.IHC 1:50-200. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 40kDa |
| Gene ID | 3916 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human LAMP1 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human LAMP1 |
| Subcellular Locations | Cell membrane Endosome membrane Late endosome Lysosome membrane Single-pass type I membrane protein |
| Swiss Prot | P11279 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. |
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