北京索萊寶科技有限公司
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服務熱線：18101056239
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
產品型號：K106537P
更新時間：2022-08-15
廠商性質：生產廠家
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產品分類
Anti-PTEN Polyclonal Antibody
| 英文名稱 | Anti-PTEN Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | 10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;PTENbeta;TEP1 |
| 應用 | WB |
| 稀釋比例 | WB 1:3000. |
| 交叉反應 | Human Mouse Rat |
| 蛋白分子量 | 47kDa |
| Gene ID | 5728 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human PTEN |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human PTEN |
| Subcellular Locations | Cytoplasm Nucleus PML body Secreted |
| Swiss Prot | P60484 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
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