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Anti-ERK1/2 Polyclonal Antibody
產(chǎn)品簡介：

Anti-ERK1/2 Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K106589P

更新時(shí)間：2022-08-15

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產(chǎn)品介紹

Anti-ERK1/2 Polyclonal Antibody

英文名稱Anti-ERK1/2 Polyclonal Antibody
宿主Rabbit
別名ERK;ERK-2;MAPK2;p38;p40;p41;p41mapk;p42-MAPK;P42MAPK;PRKM1;PRKM2
應(yīng)用WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human Mouse Rat
蛋白分子量41kDa
Gene ID5594
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human ERK1/2
性狀液體
Public Immunogen RangeRecombinant protein of human ERK1/2
Subcellular LocationsCytoplasm Nucleus Cell membrane Cytoskeleton
Swiss ProtP28482
克隆類型Polyclonal Antibody
背景資料Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation.

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