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產(chǎn)品中心抗體Polyclonal AntibodyK106765PAnti-GADD153 Polyclonal Antibody
產(chǎn)品型號：K106765P
更新時間：2022-08-14
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：961
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產(chǎn)品分類
Anti-GADD153 Polyclonal Antibody
| 英文名稱 | Anti-GADD153 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | CEBPZ;CHOP;CHOP-10;CHOP10;GADD153;C/EBPzeta;DNA damage inducible transcript 3 |
| 應(yīng)用 | IHC |
| 稀釋比例 | IHC 1:25-100. |
| 交叉反應(yīng) | Human |
| 蛋白分子量 | 19kDa |
| Gene ID | 1649 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human GADD153 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human GADD153 |
| Subcellular Locations | Nucleus Cytoplasm |
| Swiss Prot | P35638 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. |
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