Anti-ALYREF Polyclonal Antibody
應(yīng)用WB IHC
稀釋比例WB 1:5000-8000. IHC 1:100-300.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K107490P

更新時間：2022-08-13

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抗體

標(biāo)簽抗體血清球蛋白 IgG Polyclonal Antibody Antibody Monoclonal Antibody 一抗內(nèi)參抗體膠體金標(biāo)記二抗生物素化二抗 RBITC熒光標(biāo)記抗體二抗 FITC熒光標(biāo)記抗體二抗免疫血清二抗純化抗體二抗 HRP標(biāo)記二抗免疫球蛋白抗原IgG二抗

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產(chǎn)品介紹

Anti-ALYREF Polyclonal Antibody

英文名稱	Anti-ALYREF Polyclonal Antibody
宿主	Rabbit
別名	ALY;ALY/REF;BEF;REF;THOC4;THO complex subunit 4
應(yīng)用	WB IHC
稀釋比例	WB 1:5000-8000. IHC 1:100-300.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	27kDa
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human ALYREF
Subcellular Locations	Nucleus Cytoplasm
Swiss Prot	Q86V81
克隆類型	Polyclonal Antibody
背景資料	Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability.

多克隆抗體

由于多克隆抗體通常包含抗某一抗原的不同表位的抗體，所以，在深固定的樣本中也會很好地發(fā)揮效應(yīng)，在石蠟包埋組織切片的染色中，多克隆抗體常選用。根據(jù)實(shí)驗(yàn)的不同需要，多克隆抗體應(yīng)用于相應(yīng)抗原的標(biāo)記。此外，在農(nóng)業(yè)生產(chǎn)中，多克隆抗體被用于農(nóng)藥殘留現(xiàn)場監(jiān)測；在臨床應(yīng)用中，多克隆抗體主要用于病原物的檢測、疾病的診斷及治療，如作為蛋白類免疫抑制劑用于移植反應(yīng)和自身免疫病的治療。

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多克隆抗體

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